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目的 研究肝细胞生长因子及其受体c met在乳腺癌发生、发展中的作用及其与预后的关系。方法 采用文献回顾的方法并结合目前的实验研究 ,对肝细胞生长因子及受体c met在乳腺癌中的研究进展加以综述。结果 肝细胞生长因子对乳腺癌细胞具有促分裂、诱导肿瘤细胞迁移、侵袭以及诱发肿瘤血管生成的作用 ,其与受体c met作用机理的发现 ,进一步揭示了乳腺癌的发生机理。结论 肝细胞生长因子 /c met在乳腺癌发生、发展过程中起重要作用 ,对指导乳腺癌临床治疗有一定意义
Objective To study the role of hepatocyte growth factor and its receptor c met in the occurrence and development of breast cancer and its relationship with prognosis. Methods The review of literature review and current experimental studies were used to review the research progress of hepatocyte growth factor and receptor c met in breast cancer. Results The role of hepatocyte growth factor in the mitogenesis of breast cancer cells, the induction of tumor cell migration, invasion and the induction of tumor angiogenesis. The discovery of the mechanism of hepatocyte growth factor and receptor c met further revealed the mechanism of breast cancer. Conclusions Hepatocyte growth factor /c met plays an important role in the occurrence and development of breast cancer, which is of significance in guiding the clinical treatment of breast cancer.