妊娠期雌三醇的变化,反应胎儿胎盘在子宫内的状况,近年来已应用于临床,作者复习了201篇资料,提出了评价。一、妊娠期的尿中雌三醇正常妊娠期雌三醇的产生及排泄正常妊娠期雌三醇的产生大部分是来源于胎儿。它的合成,开始是在胎儿的肾上腺中产生脱氢表雄酮[dehydroepiandrosterone(DHEA),这是尿中雌三醇的主要前身物质],而后在胎儿肝脏中将DHEA16羟基化,再在胎盘中将16-OH DHEA形成游 Changes in gestational estriol, the reaction of fetal placenta in the uterus, has been applied in clinical practice in recent years, the authors reviewed 201 articles, made the evaluation. First, the gestational urine estriol normal gestational estriol production and excretion Most of the normal gestational estriol derived from the fetus. Its synthesis begins with the production of dehydroepiandrosterone (DHEA), the main precursor of urinary estriol, in the fetus’s adrenal gland and hydroxylation of DHEA16 in the fetal liver followed by the placenta The 16-OH DHEA forms a swim