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目的探讨CO中毒后迟发性脑病的临床特点,发病机制及影响预后的相关因素。方法对已经确诊的38例急性CO中毒迟发性脑病的临床资料进行研究。结果所有患者急性中毒后,均有6~45 d不等的假愈期,之后出现以痴呆、震颤麻痹和精神症状为主的脑病表现,经高压氧、改善脑循环、营养神经等治疗,有效率为92.1%,治愈率为36.8%。结论本病的预后与患者年龄、昏迷时间、假愈期、急性期高压氧治疗次数有关。提高对本病的认识是防止漏诊、误诊的关键,高压氧治疗有效。急性CO中毒后高压氧治疗的时间越早、疗程越长,预后越好。
Objective To investigate the clinical features, pathogenesis and prognostic factors of delayed encephalopathy after CO poisoning. Methods The clinical data of 38 patients with confirmed acute CO poisoning delayed encephalopathy were studied. Results All patients were acute poisoning, ranging from 6 to 45 days of false leave, followed by dementia, paralysis and psychiatric symptoms of brain disease performance, hyperbaric oxygen, to improve cerebral circulation, nourishing nerves and other treatment, there The efficiency was 92.1% and the cure rate was 36.8%. Conclusions The prognosis of this disease is related to patient’s age, coma time, false leave and acute hyperbaric oxygen therapy. To improve understanding of the disease is to prevent misdiagnosis, the key to hyperbaric oxygen therapy. The sooner the hyperbaric oxygen treatment after acute CO poisoning, the longer the course of treatment, the better the prognosis.