论文部分内容阅读
目的探讨子宫内膜异位症(EMS)患者腹腔液及血清中视黄醇结合蛋白4(RBP4)和中性粒细胞激活肽-78(ENA-78)的含量变化及其与EMS发病的关系。方法采用酶联免疫吸附法(ELISA)检测86例EMS患者和36例因卵巢囊肿或浆膜下子宫肌瘤手术患者腹腔液及血清RBP4和ENA-78含量并进行分析。结果 EMS组患者腹腔液中RBP4、ENA-78的含量明显高于对照组,两组比较差异均有统计学意义(P<0.01)。Ⅲ、Ⅳ期EMS患者腹腔液及血清中RBP4的含量较Ⅰ、Ⅱ期患者明显升高,差异也有统计学意义(P<0.01);Ⅲ、Ⅳ期EMS患者腹腔液及血清中ENA-78的含量较Ⅰ、Ⅱ期患者升高,差异有统计学意义(P<0.05)。同时EMS组患者RBP4与ENA-78的含量之间存在正相关(r=0.72,P<0.01)。结论 EMS患者腹腔中高含量的RBP4与ENA-78,可能对EMS发病有影响;EMS患者腹腔液与血清中RBP4和ENA-78含量变化且与EMS关系密切。
Objective To investigate the changes of RBP4 and ENA-78 in peritoneal fluid and serum of patients with endometriosis (EMS) and its relationship with the pathogenesis of EMS. Methods The contents of peritoneal fluid and serum RBP4 and ENA-78 in 86 patients with EMS and 36 patients with ovarian cyst or subserosal uterine fibroids were detected by enzyme linked immunosorbent assay (ELISA) and analyzed. Results The contents of RBP4 and ENA-78 in peritoneal fluid of EMS patients were significantly higher than those in control group, with significant difference between the two groups (P <0.01). The content of RBP4 in peritoneal fluid and serum of stage Ⅲ and Ⅳ EMS patients was significantly higher than that of stage Ⅰ and Ⅱ patients (P <0.01). The levels of ENA-78 in peritoneal fluid and serum in patients with stage Ⅲ and Ⅳ EMS The content was higher than that in stage Ⅰ and Ⅱ patients, the difference was statistically significant (P <0.05). At the same time, there was a positive correlation between RBP4 and ENA-78 in EMS group (r = 0.72, P <0.01). Conclusions High levels of RBP4 and ENA-78 in the peritoneal cavity of EMS patients may have an impact on the pathogenesis of EMS. The contents of RBP4 and ENA-78 in peritoneal fluid and serum of EMS patients are closely related to EMS.