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选用Ｗｉｓｔａｒ大鼠，以三氧化二砷为受试物，高剂量组约为１／１０ＬＤ５０。采用两代一窝繁殖法观察砷的生殖毒性和子代发育的变化。结果显示两代大鼠的受孕率和哺育成活率高剂量组明显低于对照组和低剂量组；而正常分娩率和幼仔出生存活率各组间无显著性差异；仔鼠体砷含量随染砷剂量的增加而逐渐增加，各组间比较均有显著性差异。仔鼠出生第１０，２０，３０天的体重高剂量组明显低于对照组和其它剂量组，具有显著性差异。说明砷可影响动物的生殖能力，并且通过哺乳使幼鼠接触到过量的砷而危及其生命。砷可以通过胎盘屏障而影响子代的生长发育。
Wistar rats were selected to arsenic trioxide as a test substance, high-dose group was about 1 / 10LD50. The reproductive toxicity and the development of offspring of arsenic were observed by two generations of litter reproduction method. The results showed that the fertilization rate and nurturing survival rate in two groups of rats were significantly lower than those in the control group and the low-dose group. However, there was no significant difference between the normal delivery rate and the survival rate of the pups. Dyeing arsenic dose increased and gradually increased, compared between the groups were significantly different. The pups were born on the 10th, 20th and 30th day of high-dose group was significantly lower than the control group and other dose groups, with significant differences. It shows that arsenic can affect the reproductive capacity of animals and endanger the life of young rats by exposing them to excess arsenic. Arsenic can affect the growth and development of offspring through the placental barrier.