瘦素是脂肪细胞分泌的蛋白质类激素,在体内分为游离型、结合型两种形式。瘦素与其受体结合后通过细胞信号转导途径发挥生物学效应。研究发现瘦素在多种慢性肝病的发生发展中起一定的作用,可能与促进肝内脂肪堆积、刺激肝星状细胞活化、促使库普弗细胞表达细胞因子、增加交感神经活性、影响细胞信号转导等机制有关。 Leptin is a protein hormone secreted by adipocytes, which is divided into two types: free form and combined form. Leptin binds to its receptors and exerts a biological effect through cellular signal transduction pathways. The study found that leptin play a role in the occurrence and development of a variety of chronic liver diseases, which may be related to the promotion of intrahepatic fat accumulation, stimulation of hepatic stellate cell activation, prompting Kupffer cells to express cytokines, increase sympathetic activity and affect cell signaling Transduction and other mechanisms.