【摘 要】
：
Metal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type aglucosidase inhibitors were synthesized and assessed in vitro f
【机 构】
：
School of Chemistry and Chemical Engineering, Sun Yat-Sen University,
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
Metal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type aglucosidase inhibitors were synthesized and assessed in vitro for inhibitory activity. All of the Ag(I)complexes(9–16) inhibited a-glucosidase at the nanomolar scale, while 3,5-dichloroanthranilic acid silver(I)(9) was the most potent(IC_(50)= 3.21 nmol/L). Analysis of the kinetics of enzyme inhibition indicated that the mechanism of the newly prepared silver complexes was noncompetitive. The structure-activity relationships were also analyzed, and they are discussed in this report.
Metal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type aglucosidase inhibitors were synthesized and assessed in vitro for inhibitory activity. All of the Ag (I) complexes (9-16) inhibited a-glucosidase at the nanomolar scale , while 3,5-dichloroanthranilic acid silver (I) (9) was the most potent (IC 50 = 3.21 nmol / L). Analysis of the kinetics of enzyme inhibition indicating that the mechanism of the newly prepared silver complexes was noncompetitive The structure-activity relationships were also analyzed, and they are discussed in this report.
其他文献
富有奇趣的新年礼物送煤炭在英国的苏格兰，元旦这天人们习惯用煤作为拜年的礼物，送到亲朋好友家中，以祝贺他们在新的一年里日子过得红火。送石头希腊克里特岛居民新年带给亲朋好
An efficient method for the synthesis of novel benzo[b]pyrimido[4’,5’:5,4]thieno[2,3e]-[1,6]naphthyridine-8-one derivatives via Pictet–Spengler cyclization i
Two new N-methyladenine-containing diterpenes,nemoechines F(l)and G(2),were isolated from the South China Sea sponge Agelas aff.nemoechinata.The structures were
《穿过漩涡》的第九章《在德国的联想》,反映了作者1996年10月参加省委批准举办的第三期市厅级干部经济管理研讨班,在德国学习考察的所见所闻。这里刊出的是其中的一篇。——
本文从专业设置、硬件设施、师资状况、课程与教学、招生与就业等方面对我国中等职业教育汽车专业人才培养状况进行了调查。分析结果表明,我国汽车专业人才培养尚存在以下制
The inclusion behaviors of three native or modified CDs including p-CD,2-hydroxypropyl-β-CD(2-Hp-β-CD) and 2,6-dimethyl-β-CD(Me-β-CD) toward 5-amino-6-methy
Uniform and well-defined lanthanide hydroxide and oxide micro/nanorods Ln(OH)_3(Ln=La, Pr, Sm, Eu, Gd, Er) and Gd(OH)_3:Eu~(3+), Gd_2O_3:Eu~(3+) were successful
Amphiphilic Janus gold nanoparticles(GNPs) are prospected to encapsulate drug molecules in cancer therapy and to serve as heterogeneous catalysts at oil/water i
对200例孕妇进行电子胎心监护,以了解西宁地区胎儿宫内缺氧电子监护出现的各种波形与Apgar评分的关系和妊娠结局。在高海拔地区加强孕妇电子胎心监护对胎儿发育生长情况及决
[目的]建立印楝中nimbin的高效液相色谱定量分析方法。[方法]采用ODS色谱柱,流动相为甲醇-水(体积比为70∶30),流速1 mL/min,检测波长UV217 nm。[结果]方法线性相关系数为0.9