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本文验证了国产盐酸地尔硫(艹卓)的一些心血管药理作用及其急性毒性。它能抑制电刺激引起的离体兔左心房收缩(IC_(50)3.35μM);对去甲肾上腺素引起的离体兔主动脉条收缩,作用很弱,但能浓度依赖性地抑制氯化钾引起的兔主动脉条收缩(IC_(50) 0.21μM)。它能有效地对抗哇巴因所致豚鼠心律失常;降低麻醉大鼠的血压约22mmHg,持续30 min-并使其心率明显减慢。小鼠口服和静脉注射的 LD_(50)值分别为34.3和335.5mg/kg。
This article validates some of the cardiovascular pharmacological effects of diltiazem hydrochloride and its acute toxicity. It can inhibit the left atrial contraction induced by electrical stimulation in vitro (IC 50 (3.35μM)). It inhibits the contraction of isolated aortic strips of noradrenaline induced by noradrenaline in a dose-dependent manner but inhibits the chloride Potassium induced contraction of rabbit aortic strips (IC 50 (0.21 μM). It is effective against guinea pig arrhythmias induced by ouabain, and reduces the blood pressure of anesthetized rats by about 22 mmHg for 30 min-and slows heart rate significantly. The LD_ (50) values of mice oral and intravenous injection were 34.3 and 335.5mg / kg, respectively.