不宁腿综合征(Restlesslegssyndrome,RLS)主要表现为双下肢难以形容的感觉异常与不适,患者被迫活动或敲打下肢以减轻其痛苦,常在夜间休息时加重。本病最早在1685年由英国Wills提出,其后1945年由Ekbom作过系统总结,第一次全面予以描述,故又称Ekbom综合征。该病发病机制和病理生 Restless leg syndrome (RLS) is characterized by indefinable sensory abnormalities and discomfort in both lower extremities. Patients are forced to move or beat lower extremities to relieve their pain and often aggravate during rest at night. The disease was first proposed by Wills in England in 1685, followed by systematic reviews by Ekbom in 1945, the first comprehensive description, it is also known as Ekbom syndrome. The pathogenesis and pathology of the disease