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近年来将Co Q_(10)作为细胞代谢和细胞呼吸激活剂,试用于休克、缺氧、心肌缺血及再灌注损伤的实验和临床治疗,据报告有较好疗效。但外源性Co Q_(10)能否进入线粒体发挥电子传递作用,尚有争议,故Co Q_(10)的治疗机理仍不清楚。将脂晚体(Liposome,具有磷脂双层分予结构的人工生物膜)作为药物载体,运送药物到达特定的组织和细胞,是非常有前途的冶疗措施,目前已应用于肿瘤,先天性酶缺乏、病毒和寄生虫感染等疾病的临床实践,但迄今未见循环休克领域里应用脂质体的报造。本工作应用脂质体携带Co Q_(10)治疗大鼠内毒毒休克,以探讨Co Q_(10)的作用机理及休克领域使用脂质体的可行性。
In recent years, Co Q_ (10) has been used as a cell metabolism and cellular respiration activator in the experimental and clinical treatment of shock, hypoxia, myocardial ischemia and reperfusion injury, and reportedly has good curative effect. However, the exogenous Co Q_ (10) can enter the mitochondria to play the role of electron transfer, there is still controversy, so the therapeutic mechanism of Co Q_ (10) is still not clear. Liposome, an artificial biofilm with phospholipid bilayer structure, is used as a drug carrier to deliver drugs to specific tissues and cells. It is a very promising therapeutic strategy and has been applied to tumors, congenital enzymes Lack of clinical practice of viruses and parasitic infections and other diseases, but so far no application of liposomes in the field of circulating shock reported. In this work, liposome-carrying Co Q_ (10) was used to treat endotoxic shock in rats to explore the mechanism of Co Q_ (10) and the feasibility of using liposomes in the field of shock.