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目的探讨PCNA和P~(21)的表达与喉非典型增生的预后是否相关。方法用免疫组化ABC法对63例喉非典型增生(其中40例转化为癌,另23例未转化),56例喉鳞癌和7例正常喉组织进行了PCNA、P~(21)检测。结果 PCNA指数和P~(21)阳性率在非典型增生转化组与癌间,来转化组与癌间均有极显著性差异(P<0.01),在转化组与未转化组间无统计学差异。结论PCNA对衡量喉非典型增生和癌的细胞增殖状态有一定的价值,P~(21)与喉癌的发生机制相关,但两者的表达均与喉非典型增生的预后无明显相关性。
Objective To investigate whether the expression of PCNA and P ~ (21) is related to the prognosis of laryngeal atypical hyperplasia. Methods PCNA, P ~ (21) were detected in 63 cases of atypical hyperplasia of larynx (40 cases converted to carcinoma and 23 cases untransformed), 56 cases of laryngeal squamous cell carcinoma and 7 cases of normal laryngeal tissue by immunohistochemical ABC method . Results PCNA index and positive rate of P ~ (21) were significantly different between atypical hyperplastic transformation group and between cancerous tissues, between transformed group and cancerous tissues (P <0.01), but not between the transformed group and the untransformed group difference. Conclusions PCNA is valuable in measuring the proliferation of laryngeal atypical hyperplasia and carcinoma of the larynx. P ~ (21) is associated with the pathogenesis of laryngeal carcinoma. However, the expression of PCNA has no significant correlation with the prognosis of laryngeal atypical hyperplasia.