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目的利用光学相干断层扫描血管造影(optical coherence tomography angiography,OCTA)技术分析健康受试者角膜及角膜上皮各区域的厚度。方法利用OCTA分析100例(男女各50例)年龄20~30岁的健康受试者,使用Angio Vue OCTA系统的视网膜成像模式,并采用SSADA算法进行成像,测量角膜中央9 mm直径范围各区域角膜及角膜上皮厚度,比较不同性别各区域角膜及角膜上皮厚度的差异性。结果男女两组受检者角膜中央总厚度分别为(559.92±33.26)μm、(540.06±31.63)μm,角膜上皮总厚度分别为(57.78±4.88)μm、(56.88±4.57)μm,男性角膜中央总厚度及角膜上皮厚度均大于女性,差异均有统计学意义(t=3.06、2.10,均为P<0.05)。男性各环角膜总厚度均在S5、S7、SN9处最厚,与女性相比,只有在S5、S7处差异显著(t=2.93、2.83,均为P<0.05),女性各环在S5、SN7、SN9处最厚,与男性相比只在S5处差异显著;男性受检者角膜在IT处最薄,与相同区域的女性受检者相比只有在IT5处差异有统计学意义(t=2.02,P<0.05);女性受检者角膜在T5、IT7、T9处最薄,与同区域的男性受检者相比只在T5、T9处差异均有统计学意义(t=2.63、2.20,均为P<0.05);在ST处男女角膜厚度差异显著(t=3.11、2.79、2.33,均为P<0.05);男性受检者角膜上皮在IT5、I7、I9处最厚,在S5、S7、S9处最薄,与同区域的女性相比差异均无统计学意义(均为P>0.05),女性受检者角膜上皮在IT5、T7、N9处最厚,在SN5、S7、S9处最薄;除M2、SN5外,角膜上皮在男女组间差异均无统计学意义(均为P>0.05)。角膜中央上皮占角膜总厚度的百分率最大,并且由内向外逐渐减小。结论 OCTA能够用于测量角膜及角膜上皮各区域的厚度。
Objective To analyze the thickness of cornea and corneal epithelium in healthy subjects by optical coherence tomography angiography (OCTA). Methods 100 OCT (50 men and women) age-matched healthy subjects aged 20-30 years were enrolled in this study. Angio Vue OCTA system was used for retinal imaging and SSADA algorithm was used for imaging. Corneas in the 9 mm diameter center were measured. And corneal epithelial thickness, the differences of corneal and corneal epithelial thickness in different regions were compared. Results The total central corneal thickness of the male and female subjects were (559.92 ± 33.26) μm and (540.06 ± 31.63) μm, respectively. The total corneal epithelial thicknesses were (57.78 ± 4.88) μm and (56.88 ± 4.57) μm, Total thickness and corneal epithelium thickness were greater than women, the differences were statistically significant (t = 3.06,2.10, both P <0.05). The total corneal thickness of each cornea was the thickest at S5, S7 and SN9, compared with that of female at S5 and S7 (t = 2.93, 2.83, both P <0.05) SN7, SN9 at the thickest, compared with men, only significant differences in the S5; male subjects corneal thinnest in IT, compared with female subjects in the same area only in the IT5 place was statistically significant (t = 2.02, P <0.05). The cornea was the thinnest at T5, IT7 and T9 in female subjects, and the difference was statistically significant only at T5 and T9 compared with male subjects in the same region (t = 2.63, 2.20, both P <0.05). There were significant differences in the thickness of cornea between men and women at ST (t = 3.11,2.79,2.33, both P <0.05). The corneal epithelium of male subjects was the thickest at IT5, I7 and I9, The thinnest at S5, S7 and S9, there was no significant difference compared with female in the same area (all P> 0.05). The female corneal epithelium was the thickest at IT5, T7 and N9, , While S9 was the thinnest. There was no significant difference in corneal epithelium between male and female groups except M2 and SN5 (all P> 0.05). The corneal central epithelium accounted for the largest percentage of total corneal thickness, and gradually decreased from the inside out. Conclusion OCTA can be used to measure the thickness of corneal and corneal epithelial regions.