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胆红素代谢的新概念胆红素的主要来源是血红蛋白。正常成人约有6～8克的血红蛋白(Hb)被代谢,Hb主要来自衰老的红细胞所产生。Hb是由珠蛋白与4个正铁血红素结合而组成,正铁血红素由原卟啉与一个二价铁原子所构成的具有特殊环状结构的化合物。正常成人每日形成的胆红素约为200～300毫克,根据Crosby的研究每日产生胆红素的最高量为1.5克。 [血清胆红素的来源] 有关生成胆红素的源泉目前了解得还不十分清楚,有人用同位素标识的菾菜硷(glycine)作静脉注射后进行观察,发现注射后的30分钟～24小时、3～4天、90～130
The new concept of bilirubin metabolism The main source of bilirubin is hemoglobin. Normal adults, about 6 to 8 grams of hemoglobin (Hb) is metabolized, Hb mainly from the aging of red blood cells. Hb is a combination of globin and 4 hemins, a compound with a special ring structure consisting of protoporphyrin and a divalent iron atom. Normal adult daily formation of bilirubin is about 200 ~ 300 mg, according to Crosby study daily maximum bilirubin production of 1.5 grams. [Source of serum bilirubin] The source of bilirubin production is currently not well understood, it was observed with isotope-labeled glycine for intravenous injection and found that 30 minutes to 24 hours after injection , 3 ~ 4 days, 90 ~ 130