目的:寻找有效的抗黄病毒药物，为临床应用提供理论依据。方法:运用病毒滴定法和Western blot法，在培养细胞的增殖系中投入抗菌药氧氟沙星(OFLX)，观察其对病毒增殖的影响。结果:用OFLX(10 μg·ml-1)处理后产生的病毒量是对照组的61%，病毒E蛋白量合成减少。结论:OFLX对抑制病毒增殖有一定效果。 Objective: To find effective anti-flavivirus drugs, provide a theoretical basis for clinical application. Methods: By using titration and Western blotting, OFLX was injected into the proliferating cell line of cultured cells to observe its effect on virus proliferation. Results: After treatment with OFLX (10 μg · ml-1), the amount of virus produced was 61% of the control and the amount of virus E protein was reduced. Conclusion: OFLX can inhibit the proliferation of the virus to a certain extent.