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用两种方法合成了7个新型的手性多元β-酰胺醇。方法1是多元羧酸与SOCl2反应形成相应的多元酰氯,然后与手性α-氨基醇反应合成了目标物,产率为3·7%~78·8%。方法2是在N2保护120~145℃下,多元羧酸与手性α-氨基醇反应3~12h,一步反应合成了目标物,产率为71·2%~95·7%。
Seven novel chiral polybasic β-amidols were synthesized by two methods. Method 1 is the reaction of polycarboxylic acids with SOCl2 to form the corresponding polyacid chlorides, and then the target compounds are synthesized by reaction with chiral α-amino alcohols. The yield is from 3.7% to 78.8%. Method 2 is to react polycarboxylic acid with chiral α-amino alcohol at 120-145 ° C for 3 to 12 hours under N2 protection. The target compound is synthesized in one step with the yield of 71.2% -95.7%.