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贵刊1986年第9期刊登的《青霉素在0.9%氯化钠注射液中的稳定性》一文,读后认为有值得商榷的两处,指出供讨论。 1.原文实验材料中0.9%氯化钠注射液pH为3.5,不知作者所在医院生产本品做何应用?若用于临床静脉滴注,则是错误的,因为中国药典1977年版和1985年版二部收载的0.9%氯化钠注射液,其pH值控制范围都是4.5～7.0,达不到或超过都应视为不符合规定。显而易见,不合格药品是不能生产的,更应禁止使用,用于指导临床合理用药的实验考察亦不可取。
The article entitled “Stability of Penicillin in 0.9% Sodium Chloride Injection” published in Issue 9, 1986, read two articles that are debatable and is for discussion. 1. The original experimental material 0.9% sodium chloride injection pH 3.5, I do not know where the author’s hospital for the production of this product do? If used for clinical intravenous drip, it is wrong, because the Chinese Pharmacopoeia 1977 edition and 1985 edition two Department contained 0.9% sodium chloride injection, the pH control range is 4.5 to 7.0, up to or beyond should be considered as non-compliant. Obviously, substandard drugs can not be produced, but should be banned from use, to guide clinical rational use of the experimental study is not desirable.