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乙胺碘呋酮早在1961年在欧州作为抗心绞痛药,其后欧州与南美州又广泛用于抗心律失常。长期用药者常见的副作用为角膜微小沉集,而便秘、光敏性皮炎、头痛、恶心、甲状腺机能亢进(或减退)、末梢神经炎等少见。Rotmensch等1980年曾报告一例用该药后发生肺部浸润。本文报告423例严重心律紊乱者用乙胺碘呋酮过程中,6例出现不能用其他原因解释的肺部损害。6例均为心脏病引起的严重室性心律失常。经常规抗心律失常药物治疗因无效或副作用严重而改用乙胺碘呋酮,此后心律失常消除,但在维持治疗过程中
Amiodarone was used as an anti-anginal drug in Europe as early as 1961, and was used extensively in anti-arrhythmias in Europe and South America. Common side effects of long-term medication for the corneal micro-sedimentation, and constipation, photosensitive dermatitis, headache, nausea, hyperthyroidism (or decreased), peripheral neuritis rare. Rotmensch et al. Reported a case of pulmonary infiltration after using the drug in 1980. This article reports 423 cases of severe heart rhythm disorder with amiodarone in the process, 6 cases of lung damage can not be explained by other reasons. All the 6 cases were serious ventricular arrhythmias caused by heart disease. Routine antiarrhythmic drug therapy due to ineffective or serious side effects and switch to amiodarone, arrhythmia since then, but in the maintenance of the treatment process