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内毒素能诱导小鼠胸腺细胞凋亡,表现为凋亡细胞及凋亡小体明显增多,凋亡细胞百分率及DNA断裂百分率明显升高,琼脂糖凝胶电泳出现明显的细胞凋亡特有的“梯状”条带.用中药开闭复方后上述表现明显减轻,“梯状”条带不明显.结果提示:开闭复方对内毒素诱导的小鼠胸腺细胞凋亡有保护作用.
Endotoxin can induce apoptosis of mouse thymocytes with apoptotic cells and apoptotic bodies increasing, and the percentage of apoptotic cells and percentage of DNA breaks increased significantly. Agarose gel electrophoresis shows distinct apoptosis. Ladder-shaped “band. After opening and closing the compound with traditional Chinese medicine, the above performance was significantly reduced, and the ”ladder" band was not obvious. The results suggest that the opening and closing compound has a protective effect on endotoxin-induced mouse thymocyte apoptosis.