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近些年来,我国伤寒杆菌的普遍耐药、多元耐药已成为严重问题,来自暴发流行地区的伤寒菌株远比散发地区的菌株耐药严重,这主要是由于菌株携带接合型R质粒,使得伤寒杆菌通过获得R质粒由敏感菌变为耐药菌,使慢性带菌者广泛存在与积累,这给一些地区的伤寒暴发流行埋下了隐患;又因经济的发展促使流动人口的大量增加,无形之中又为伤寒的传播流行驾设了“桥梁”。基于以上几种因素,这些年来黑龙江省伤寒多是散在发生,病例分布较广,波及全省的91%市县,甚至部分地区发生了多起暴发流行,控制与降低伤寒的发病率是我国传染病防治中的一项重要任务。因此,加强黑龙江省伤寒病的防治工作尤其重要。
In recent years, the universal drug resistance and multivariate drug resistance of Salmonella Typhi in China have become serious problems. Typhoid strains from outbreak areas are far more resistant than those in the outbreak areas. This is mainly due to strains carrying R-type plasmids that cause typhoid fever Bacteria by the R plasmid by the sensitive bacteria into resistant bacteria, chronic carriers of widespread and accumulation, which to some areas of typhoid outbreak of the hidden dangers; and because of economic development to promote a substantial increase in the floating population, invisible In the spread of typhoid epidemic and set up a “bridge.” Based on the above factors, the number of typhoid fever in Heilongjiang Province in recent years is mostly scattered. The cases are widely distributed and affected 91% of counties and counties in the province. Some outbreaks have even occurred in some areas. The incidence of typhoid fever is controlled and reduced in China Disease prevention and treatment of an important task. Therefore, strengthening the prevention and treatment of typhoid fever in Heilongjiang Province is particularly important.