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目的评价波依定合用氟伐他汀对原发性高血压左室肥厚的影响。方法将80例原发性高血压左室肥厚患者随机分为A、B两组,A组给予波依定5 mg/d;B组给予波依定5 mg/d+氟伐他汀40 mg/d。疗程6个月,治疗前后用放免法测定血清中Ⅲ型前胶原(PCⅢ)、NO含量。分别在用药前后用超声心动图检查评价心肌肥厚。结果两组患者药物治疗后血压降低的同时LVM I及血清PCⅢ浓度也较治疗前降低(P<0.01),B组血清PCⅢ浓度的降低较A组更明显(P<0.05),LVM I的降低在两组间差异有统计学意义(P<0.05),B组治疗后NO的变化明显高于A组(P<0.05)结论波依定合用氟伐他汀对原发性高血压左室肥厚逆转及舒张功能改善有协同作用,较单一用药疗效显著。
Objective To evaluate the effect of fluvastatin combined with fluvastatin on left ventricular hypertrophy in patients with essential hypertension. Methods Eighty patients with essential hypertension with left ventricular hypertrophy were randomly divided into A and B groups. A group received 5 mg / day of doxepin, and group B received 5 mg / day of fludizine and 40 mg of fluvastatin . Treatment for 6 months, before and after treatment by radioimmunoassay of serum type Ⅲ procollagen (PC Ⅲ), NO content. Before and after treatment with echocardiography to assess myocardial hypertrophy. Results Compared with before treatment, LVM I and serum PCIII levels were decreased (P <0.01). The serum PCⅢ concentration in group B was significantly lower than that in group A (P <0.05) and LVM I was decreased The difference between the two groups was statistically significant (P <0.05), and the change of NO in group B after treatment was significantly higher than that in group A (P <0.05). Conclusion Wave-dependent combination of fluvastatin reversed left ventricular hypertrophy in patients with essential hypertension And systolic and diastolic function have a synergistic effect, compared with a single drug significant effect.