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目的观察低分子肝素钙联合复方丹参注射液对肾病综合征型早发型子痫前期围产结局的影响。方法将80例肾病综合征型早发型子痫前期患者按自愿原则分为硫酸镁组(A组,22例),硫酸镁加低分子肝素钙组(B组,19例),硫酸镁加丹参组(C组,21例),硫酸镁加低分子肝素钙加丹参组(D组,18例)。比较各组脐动脉S/D比值、羊水指数、延长孕龄时间、新生儿体重、胎盘重量、Apgar评分。结果与本组治疗前比较,四组治疗后S/D降低(P<0.05),A组羊水指数降低(P<0.05),B、C、D组羊水指数升高(P<0.05)。与A组同期比较,B、C、D组治疗后S/D降低(P<0.01,P<0.05),羊水指数升高(P<0.01,P<0.05);B、C、D组延长孕龄时间及新生儿体重升高(P<0.01,P<0.05);B、D组胎盘重量升高(P<0.05);D组1 min、5 min Apgar评分改善(P<0.05)。与B、C组同期比较,D组治疗后S/D降低(P<0.05),羊水指数升高(P<0.05)。与B组比较,C组延长孕龄时间及胎盘重量降低,D组延长孕龄时间及胎盘重量升高(P<0.05)。与C组比较,D组延长孕龄时间、胎盘重量、新生儿体重升高(P<0.05)。结论应用低分子肝素钙联合复方丹参注射液治疗肾病综合征型早发型子痫前期可延长孕龄,明显改善围产结局,效果优于单独使用。
Objective To observe the effect of low molecular weight heparin combined with compound Salvia miltiorrhiza injection on perinatal outcome of nephrotic syndrome type early preeclampsia. Methods Eighty patients with early-onset preeclampsia of nephrotic syndrome were divided into two groups based on the voluntary principle: magnesium sulfate group (group A, n = 22), magnesium sulfate plus low molecular heparin calcium group (group B, n = 19), magnesium sulfate plus salvia miltiorrhiza Group C (21 cases), magnesium sulfate plus low molecular weight heparin plus Salvia group (Group D, 18 cases). Umbilical artery S / D ratio, amniotic fluid index, prolonged gestational age, weight of newborn, placental weight, Apgar score were compared between groups. Results Compared with before treatment, the S / D of the four groups decreased (P <0.05), the amniotic fluid index of group A decreased (P <0.05), and the index of amniotic fluid of group B, C and D increased (P <0.05). Compared with group A, the S / D decreased (P <0.01, P <0.05) and amniotic fluid index increased in groups B, C and D (P <0.01, P < (P <0.01, P <0.05). The weight of placenta in group B and D increased (P <0.05). The score of Apgar improved in group D at 1 and 5 min (P <0.05). Compared with group B and C, the S / D of group D decreased (P <0.05) and the amniotic fluid index increased (P <0.05). Compared with group B, group C prolonged gestational age and reduced placental weight, while group D prolonged gestational age and increased placental weight (P <0.05). Compared with group C, group D prolonged gestational age, weight of placenta and weight of neonates (P <0.05). Conclusion Low molecular weight heparin combined with compound Danshen injection for nephrotic syndrome early preeclampsia can extend gestational age, significantly improve perinatal outcomes, the effect is better than alone.