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滋养细胞在妊娠高血压综合征(PIH)病因学中的作用日益引起重视。滋养细胞数目的改变,毒性作用,浸润能力的改变以及免疫学方面的异常在PIH的发生过程中起决定性作用。滋养细胞可合成多种细胞因子,其中很多因子与PIH的发生有密切的关系。胎盘中大量滋养细胞的凋亡可能影响PIH的发生和结局。对其深入研究对PIH的发生机制和临床治疗有重要意义。
The role of trophoblasts in the etiology of pregnancy-induced hypertension (PIH) has drawn increasing attention. Changes in the number of trophoblasts, toxic effects, changes in invasive ability and immunological abnormalities play a decisive role in the pathogenesis of PIH. Trophoblast cells can synthesize a variety of cytokines, many of which are closely related with the occurrence of PIH. Apoptosis of a large number of trophoblasts in the placenta may affect the occurrence and outcome of PIH. Its in-depth study on the pathogenesis of PIH and clinical treatment of great significance.