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目的:利用数字化钼靶X线检查方法,监测西宁地区使用激素替代疗法的围绝经期妇女的乳腺钼靶X线变化,了解血清中雌、孕激素等水平与乳腺钼靶X线改变的关系,从而进一步指导临床用药。方法:选择在2010年5月—2013年5月期间的激素替代治疗6个月的西宁地区围绝经期妇女50例,激素替代治疗前及治疗后6个月行乳腺数字化钼靶X线检查和血清学检查,自身前后对比。结果:本组西宁地区围绝经期妇女使用激素替代疗法后乳腺腺体体积有明显的增加,血清中雌二醇、孕酮的激素水平明显升高,促卵泡刺激素、促黄体生成素的水平较前降低,治疗前后差异具有显著性(P<0.01)。结论:激素替代疗法的长期使用,可使乳腺腺体体积增加,性激素水平明显改善,乳腺数字化钼靶X线检查作为激素替代治疗中乳腺监测方法是行之有效的。
OBJECTIVE: To monitor the mammographic X-ray changes of mammograms in women with perimenopausal women using hormone replacement therapy in Xining, and to explore the relationship between estrogen and progestin in serum and mammographic X-ray changes by using digital mammography X-ray examination. To further guide the clinical medication. Methods: Fifty cases of perimenopausal women in Xining during 6 months after hormone replacement therapy between May 2010 and May 2013 were selected. Molybdenum target mammography was performed before and 6 months after hormone replacement therapy. Serological tests, before and after their own contrast. Results: The volume of mammary glands in perimenopausal women in Xining area increased significantly after hormone replacement therapy. The levels of serum estradiol and progesterone were significantly increased, and the levels of follicle-stimulating hormone, luteinizing hormone Compared with before treatment, the difference was significant (P <0.01). Conclusion: The long-term use of hormone replacement therapy can increase the volume of mammary glands and the level of sex hormones. Molybdenum target mammography in mammography is effective as a monitoring method of breast replacement in hormone replacement therapy.