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目的对奥曲肽（Octreotide）治疗晚期血吸虫病食管、胃静脉曲张大出血的疗效作出评价。方法将96例病人分为3组，A组32例，用垂体后叶素0．2u／min静脉持续注射，24h后减半剂量连续用3d。B组34例，垂体后叶素的用法同A组，同时加用硝酸甘油10～40μg／min持续静脉注射4d。C组30例，用奥曲肽100μg静脉注射后，以25μg／h的速度持续静脉注射，24h后减半剂量维持1d。结果3组止血率，分别为56．2％（18／32）、50．0％（17／34）及86．7％（26／30），C组明显优于A组与B组（P＜0．05）。3组止血有效的病例停药后1周内的再出血率，分别为2／18、2／17及5／26，无显著差异（P＞0．05）。结论奥曲肽的疗效明显优于垂体后叶素及硝酸甘油。
Objective To evaluate the efficacy of octreotide in treating esophageal and gastric variceal bleeding in advanced schistosomiasis. Methods Ninety-six patients were divided into three groups. Group A (n = 32) was continuously injected with pituitrin (0.2u / min) intravenously. B group 34 cases, the use of vasopressin with group A, plus nitroglycerin 10 ~ 40μg / min continuous intravenous injection of 4d. In group C, 30 patients were injected intravenously with octreotide 100μg and then injected intravenously at a rate of 25μg / h. After half an hour, the dose was maintained for 1d. Results The rates of hemostasis were 56.2% (18/32), 50.0% (17/34) and 86.7% (26/30) respectively in group C, which were significantly better than those in group A and group B <0.05). There was no significant difference (P> 0.05) in the rate of rebleeding within 1 week after stopping the three groups of hemostasis effective cases, which were 2/18, 2/17 and 5/26 respectively. Conclusion The efficacy of octreotide is obviously better than pituitrin and nitroglycerin.