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目的:探讨慢性胃炎、异型增生、胃癌幽门螺杆菌(HP)感染与诱导型NO合酶(iNOS)表达的关系。方法:选取我院2002~2005年胃粘膜组织标本124例,同时采集血清。其中慢性胃炎(Ⅰ组)58例,异型增生(Ⅱ组)41例,胃癌(Ⅲ组)25例。各组均采用酶联免疫法及免疫组化法检测HP抗体和iNOS表达水平。结果:iNOS的表达随胃粘膜病变的进展逐级增高,且HP阳性者iNOS表达高于HP阴性者(P<0.05)。结论:iNOS可能参与了HP感染引起的胃粘膜癌变过程并发挥了重要作用。
Objective: To investigate the relationship between chronic gastritis, dysplasia, Helicobacter pylori (HP) infection and inducible nitric oxide synthase (iNOS) expression in gastric cancer. Methods: A total of 124 gastric mucosal specimens from 2002 to 2005 in our hospital were collected, and serum was also collected. There were 58 cases of chronic gastritis (group Ⅰ), 41 cases of dysplasia (group Ⅱ) and 25 cases of gastric cancer (group Ⅲ). All groups were detected by enzyme-linked immunosorbent assay and immunohistochemistry HP antibody and iNOS expression levels. Results: The expression of iNOS increased progressively with the progress of gastric mucosal lesions, and the positive expression of iNOS in HP positive patients was higher than that in negative patients (P <0.05). Conclusion: iNOS may play an important role in the carcinogenesis of gastric mucosa induced by HP infection.