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目的:探讨D-二聚体检测对结肠癌患者的临床意义。方法:随机选择2012年12月-2014年12月我院收治的50例结肠癌患者为观察组,选择同期的50例健康体检者为对照组,检测两组人群的D-二聚体水平。研究发生转移的结肠癌和未发生转移结肠癌患者之间的D-二聚体水平的差异和临床分期与D-二聚体含量之间的关系。结果:观察组中D-二聚体检测阳性率为52.00%,而对照组检出率为0,组间比较,差异有统计学意义(P<0.05)。转移性结肠癌患者的D-二聚体水平显著高于未发生转移结肠癌患者(P<0.05)。结肠癌Ⅱ、Ⅲ、Ⅳ期患者的D-二聚体水平依次递增,各分期间具有显著性差异(P<0.05)。结论:D-二聚体水平与结肠癌患者病情相关,病情越严重,D-二聚体水平越高。
Objective: To investigate the clinical significance of D-dimer detection in patients with colon cancer. Methods: Fifty patients with colon cancer who were treated in our hospital from December 2012 to December 2014 were randomly selected as the observation group. Fifty healthy subjects at the same period were selected as the control group, and the D-dimer levels were measured in both groups. Differences in D-dimer levels and clinical stage to study the relationship between D-dimer levels between colon cancer with and without metastatic colon cancer were studied. Results: The positive rate of D-dimer in the observation group was 52.00%, while the detection rate of the control group was 0, the difference was statistically significant (P <0.05). D-dimer levels were significantly higher in patients with metastatic colon cancer than those without metastatic colon cancer (P <0.05). The levels of D-dimer in patients with stage II, III and IV colon cancer increased in sequence with significant difference (P <0.05). Conclusion: The level of D-dimer is related to the condition of colon cancer patients. The more severe the disease, the higher the level of D-dimer.