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本文观察黑木耳对实验性动脉粥样硬化(AS)家兔AS病变及有关生化指标的影响。实验结果,黑木耳有降低血浆胆固醇(TC)、过氧化脂质(LPO)、血栓素A_2(TXA_2)的含量,提高前列环素/血栓素A_2(PGI_2/TXA_2)比值,减轻AS病变的作用。表明黑木耳具有抗AS作用。其机理可能是通过降血TC,保护动脉内膜,抑制血小板聚集,并由此抑制TXA_2合成;血TC降低亦可减少脂质过氧化,从而使环氧化酶、TXA_2合成酶活性降低,TXA_2合成减少。黑木耳通过以上途径维系PGI_2/TXA_2平衡,保护血管完整性的内环境相对稳定,对抗动脉粥样硬化的发生。
This article observed the effects of black fungus on AS lesions and related biochemical parameters in experimental atherosclerosis (AS) rabbits. Experimental results show that black fungus has lower plasma cholesterol (TC), lipid peroxidation (LPO), and thromboxane A 2 (TXA 2) content, and increases the ratio of prostacyclin/thromboxane A 2 (PGI 2 /TXA 2) and reduces AS lesions. . Show that black fungus has anti-AS effect. The mechanism may be through lowering blood TC, protecting the arterial intima, inhibiting platelet aggregation, and thus inhibiting the synthesis of TXA 2; blood TC reduction can also reduce lipid peroxidation, thus reducing the activity of cyclooxygenase and TXA 2 synthase, TXA_2 Reduced synthesis. The black fungus maintains the balance of PGI_2/TXA_2 through the above methods, and the internal environment that protects the integrity of blood vessels is relatively stable against the occurrence of atherosclerosis.