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目的 :为进一步了解近年广州地区流行性出血热 (EHF)的临床和流行病学特点。方法 :对 5 8例EHF患者的临床及流行病学资料进行综合分析。结果 :( 1)肝、肾损害发生率分别为 87 5 %和 92 9% ,分别有87 9%和 81%的患者出现蛋白尿和血小板减少 ;心电图改变发生率为 81 3 % ;( 2 )EHF病毒重叠乙型肝炎病毒(HBV)感染率高达 4 7 1% ( 2 4 5 1) ,但单纯感染组与重叠感染组比较 ,两组的肝损害发生率并无显著性差异 (P>0 0 5 ) ;( 3 )临床分型属重型和危重型共占 4 8 3 % ,但具有典型临床五期经过者仅为 3 9 7% ;( 4 )本病在春季( 1～ 3月 )多发 ,多见于男性青壮年民工和农民 ;18 9%病例病前有明确鼠类接触史。结论 :本地区EHF重型和危重型病例较多 ,病死率较高 ,近年收治病人逐年增多 ,应引起重视。
Objective: To further understand the clinical and epidemiological characteristics of epidemic hemorrhagic fever (EHF) in Guangzhou in recent years. Methods: The clinical and epidemiological data of 58 EHF patients were analyzed comprehensively. Results: (1) The incidence of liver and kidney damage were 87.5% and 92.9% respectively, with proteinuria and thrombocytopenia in 87.9% and 81%, respectively; the incidence of ECG changes was 81.3%; (2) EHF virus overlap hepatitis B virus (HBV) infection rate as high as 471% (2451), but simple infection group and overlapping infection group, the two groups had no significant difference in the incidence of liver damage (P> 0 (3) The clinical classification was heavy and critical, accounting for 483% of all cases, but only 397% of those with typical clinical stage 5 were treated. (4) In the spring (January to March) Multiple, more common in young men and young men and peasants; 18 9% of cases before the onset of a clear history of murine contacts. Conclusion: There are more cases of severe and severe cases of EHF in our region and the case fatality rate is higher. In recent years, the number of cases of patients with EHF has been increasing year by year.