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对120例多囊卵巢综合征(PCOS)患者测定血清中睾酮(T)、雄烯二酮(A)、硫酸去氢表雄酮(DHEAS)及17α-羟孕酮(17α-OHP)含量,并与对照组相比较,观察PCOS患者几种雄激素水平的变化及其间的相互关系。结果显示:PCOS患者血清T、A、DHEAS值均明显高于正常组,且在LH/FSH≥2的PCOS组中表现更为明显。PCOS患者中55.5%有T高于正常范围,33.3%有A的异常,24.2%有DHEAS的升高。因此在PCOS的诊断中,LH的增高,T和/或A的增高是激素水平方面诊断PCOS的最好指标。当DHEAS增高时,给予地塞米松可提高治疗的敏感性
Serum levels of testosterone (T), androstenedione (DHEA), DHEAS and 17α-OHP were measured in 120 patients with PCOS, Compared with the control group, we observed the changes of several androgen levels in PCOS patients and their interrelations. The results showed that the serum T, A and DHEAS values of PCOS patients were significantly higher than those of normal group, and were more obvious in the PCOS group with LH / FSH≥2. 55.5% of PCOS patients had T higher than the normal range, 33.3% had abnormalities of A, and 24.2% had elevated DHEAS. Therefore, in the diagnosis of PCOS, LH increased, T and / or A increase is the best indicator of hormone levels in the diagnosis of PCOS. Dexamethasone improves the sensitivity of treatment when DHEAS increases