表皮葡萄球菌感染中的耐药性是一个严重的问题,其多种临床分离株对多达8种不同抗生素均有耐药性。法尼醇是许多植物所必须的一种成分,被发现对表皮葡萄球菌有活性。通过一种对照菌株,发现法尼醇对于生物被膜细菌作用不大,但却检测到生物膜生物量的大幅降低,由此假设法尼醇可能诱导生物膜的脱落。为验证该假设的正确性,本研究使用了36株来自不同地区的代表性表皮葡萄球菌临床分离株,并应用多位点序列分型和葡萄球菌盒式染色体mec(SCC mec)对其基因多样性特征进行描述。测试不同菌株的生物膜形成过程,并检测ica、bhp和aap基因的存在。能形成更强生物膜的菌株往往具有ica Drug resistance in Staphylococcus epidermidis infections is a serious problem with many clinical isolates resistant to as many as 8 different antibiotics. Farnesol is an essential component of many plants and was found to be active against Staphylococcus epidermidis. Through a control strain, it was found that farnesol did little to biofilm bacteria, but a substantial decrease in biofilm biomass was detected, suggesting that farnesol may induce biofilm shedding. To verify the validity of this hypothesis, we used 36 clinical isolates of Staphylococcus epidermidis from different regions and used multiple site sequence typing and staphylococcal cassette mec (SCC mec) gene diversity Sexual characteristics are described. The biofilm formation of different strains was tested and the presence of the ica, bhp and aap genes was examined. Strains that form stronger biofilms often have ica