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迄今,多发性硬化(MS)脑脊液生物学标志物中用于临床的仅有寡克隆区带和IgG鞘内合成率,其最重要的制约因素为:生物学标志物研究所需的样本量很大,单一研究中心很难达到,因此多方合作已成为趋势。脑脊液标本的采集和保存很重要。2007年3月,欧洲MS生物学标志物协作网(BioMS-eu)在伦敦召开会议,拟定了MS患者脑脊液采集、分装、储存以及相关数据收集的方案,并于2009年12月1日在Neurology杂志发表。现简要介绍如下。 1 脑脊液标本收集及注意事项 (1) 采集量:至少12mL,采集此量不会引起低颅压。因不同段脑脊液蛋白质浓度不同,建议取最初2mL用于常规检查,其余部分混匀后
To date, only the presence of oligoclonal bands and IgG intrathecal synthetic rates for clinical markers of cerebrospinal fluid biomarkers of multiple sclerosis (MS) has the most important constraints: the sample size required for biomarker studies is very high Large, single research center is difficult to achieve, so multi-cooperation has become a trend. Cerebrospinal fluid specimens collection and preservation is very important. In March 2007, BioMS-eu held a meeting in London to prepare a plan for collecting, dispensing, storing and collecting cerebrospinal fluid in MS patients and related data collection. On December 1, 2009, BioMS- Neurology published. Now brief introduction is as follows. A collection of cerebrospinal fluid specimens and precautions (1) collection volume: at least 12mL, collecting this amount will not cause low intracranial pressure. Due to different concentrations of cerebrospinal fluid protein concentration, it is recommended to take the first 2mL for routine examination, the remaining part of the mix