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Wnt基因家族编码了一组富含牛胱氨酸的糖基化蛋白质,属于分泌型生长因子。Wnt基因最初是在小鼠乳腺癌中作为原癌基因被克隆出来的。进一步研究表明该家族参与了细胞增值、分化、凋亡和细胞定位控制等过程。由wnt蛋白及其受体frizzled介导的信号通路不仅在无脊椎到物和脊椎动物的发育过程中起到关键的作用,而且该通路的功能障碍还与肿瘤及阿尔茨海默病的发病有关。最近,Marie B等还发现在外伤所致的创口愈合过程中wnt蛋白的表达,显示它可能参与了创伤的修复过程。而心肌组织在发生急性梗死后,也有一个创伤的愈合修复过程,对于急性心肌梗死后梗死区的修复及愈合过程进行的研究初步表明wnt-frizzled信号途径在其中也发挥着重要的作用。
The Wnt gene family encodes a group of cysteine-rich glycosylated proteins that are secreted growth factors. The Wnt gene was originally cloned as a protooncogene in mouse breast cancer. Further studies show that the family is involved in the process of cell proliferation, differentiation, apoptosis and cell location control. The frizzled-mediated signaling pathway by the wnt protein and its receptor not only plays a key role in the development of invertebrates and vertebrates, but also the dysfunction of this pathway is also associated with the development of tumors and Alzheimer’s disease . More recently, Marie B et al. Also found that wnt protein expression during trauma-induced wound healing suggests that it may be involved in the wound repair process. Myocardial tissue after acute infarction, but also a healing process of wound healing, infarction in acute myocardial infarction repair and healing process preliminary study showed that wnt-frizzled signaling pathway in which also plays an important role.