普罗帕酮(propafenone,PPF)是一个高效低毒的新型抗心律失常药物(结构式见图1)。临床常用于防治室性或室上性快速型心律失常;起效迅速,疗效确切,深受临床的欢迎。由于PPF半衰期波动大,病人血药浓度差异很大;进一步研究发现PPF的主要活性代谢产物5-羟基普罗帕酮(5-hydroxypropafenone,5-OHP)及N-去丙基普罗帕酮(N-depropylpropafenone,NDP)(结构式见图1)在人体内均有较强的抗心律失常活性。为了进 Propafenone (PPF) is a new type of antiarrhythmic drug with high potency and low toxicity (see Figure 1 for structure). Clinical commonly used in the prevention of ventricular tachycardia or supraventricular tachyarrhythmias; rapid onset, the exact effect, by the clinical welcome. Due to the large fluctuation of the half-life of PPF, the plasma concentration of patients varied greatly. Further studies showed that 5-hydroxypropafenone (5-OHP) and N-propylpropafenone (N- depropylpropafenone, NDP) (structural formula shown in Figure 1) have strong anti-arrhythmic activity in the human body. To enter