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皮肤是人体最大的器官,也是外源化学物入侵机体的第一道天然屏障。化学物作用于皮肤常常导致接触性过敏性皮炎。传统上常常采用豚鼠致敏试验来评价化学物的致敏性。然而,动物试验周期长,结果主观性强,变异程度大,加之如今动物保护主义对动物福利的呼声高涨,替代试验成为必然的发展趋势。本文拟就近年来在皮肤变态反应研究中的替代试验方法进行综述。
The skin is the largest organ in the body and the first natural barrier against which foreign chemicals invade the body. Chemicals acting on the skin often result in contact allergic dermatitis. Guinea pig sensitization tests have traditionally been used to assess the sensitization of chemicals. However, the long period of animal experiments, the subjectivity of the results and the large degree of variation, combined with the increasing calls for animal welfare by animal protectionists, have become inevitable trends in alternative tests. In this paper, we review the alternative test methods in skin allergy research in recent years.