国产“万古霉素”华北制药厂自投产至今已有十多年的历史,但与国外万古霉素相比,显示的生物效价与色谱行为不完全相同。经核磁共振(~1HNMR和~(13)CNMR)、快原子轰击质谱(FABMS)及其水解产物的分析测定,表明国产“万古霉素”分子中不含N-甲基亮氨酸而只含亮氨酸。分子的其余结构部分与万古霉素完全相同。从而证明国产“万古霉素”实际上是N-去甲基万古霉素。 Domestic “vancomycin” North China Pharmaceutical Factory since its production has been more than 10 years of history, but compared with the foreign vancomycin, biological potency and chromatographic behavior is not exactly the same. The result of NMR (~ 1HNMR and ~ (13) CNMR) and fast atom bombardment mass spectrometry (FABMS) and their hydrolyzate showed that domestic vancomycin did not contain N-methyl leucine but only Leucine. The rest of the molecule is exactly the same as vancomycin. Thus proved that domestic “vancomycin” is actually N-desmethyl vancomycin.