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目的:探讨输尿管大细胞神经内分泌癌的病因、临床病理特征、诊断及治疗。方法:回顾性分析我院收治的1例输尿管大细胞内分泌癌患者的临床资料:CT检查提示右肾积水、右输尿管下段占位性病变;输尿管镜检查结果倾向于尿路上皮癌。由于患者肾功能较差,行肿瘤局灶切除+输尿管端端吻合术,结果:术后病理检查回报为大细胞神经内分泌癌。术后随访18个月,未见肿瘤复发及转移。结论:输尿管大细胞神经内分泌癌是一种极罕见的恶性肿瘤,确诊需依靠病理及免疫组织化学检查。因发病率极低,其治疗尚无统一标准,早期手术切除对于改善其预后具有重要作用。
Objective: To investigate the etiology, clinicopathological features, diagnosis and treatment of ureteral large cell neuroendocrine carcinoma. Methods: The clinical data of one case of ureteral large cell endocrine carcinoma admitted to our hospital were retrospectively analyzed. CT examination revealed right hydronephrosis and space-occupying lesions of lower right ureter. Ureteroscopy showed a tendency of urothelial carcinoma. Due to poor renal function in patients with tumor resection of the ureter end anastomosis, the results: postoperative pathological examination for large cell neuroendocrine cancer. All the patients were followed up for 18 months. No tumor recurrence and metastasis were found. Conclusion: Ureteral large cell neuroendocrine carcinoma is an extremely rare malignant tumor. The diagnosis depends on pathology and immunohistochemistry. Due to the extremely low incidence, there is no uniform standard for its treatment. Early surgical resection plays an important role in improving its prognosis.