消化性溃疡(Pu)是世界上最常见的多发病之一,其发病率可高达10%左右,男性约10～15%,女性约5～10%,十二指肠溃疡(DU)明显多于胃溃疡(GU)。1963年 Shay 等提出 Pu 系攻击因子和防御因子间的动态平衡失调理论,已为广大医务工作者所接受。本文仅就近年来有关 Pu 的病理生理进展作一概述。正常人的胃液分泌和防御 Peptic ulcer (Pu) is one of the most common polyps in the world with the incidence of up to about 10%, male about 10 to 15%, female about 5 to 10%, duodenal ulcer (DU) significantly more In gastric ulcer (GU). In 1963, Shay et al proposed the theory of dynamic balance imbalance between attacking factor and defensive factor of Pu system, which has been accepted by medical workers. This article only summarizes the pathophysiological progress of Pu in recent years. Normal gastric juice secretion and defense