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目的系统评价血管内皮因子(vascular endothelial growth factor,VEGF)基因936C/T多态性与子痫前期(preeclampsia,PE)发病风险的相关性。方法计算机检索Pub Med、EMbase、The Cochrane Library(2014年第11期)、CBM、CNKI、VIP和Wan Fang Data,查找关于VEGF基因936C/T多态性与PE发病风险相关性的病例-对照研究,检索时限均为建库至2014年11月。由2位评价员按照纳入与排除标准独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用Rev Man 5.3软件进行Meta分析。结果最终纳入9个病例-对照研究,共计904例PE患者和1 113例对照。Meta分析结果显示,VEGF基因936C/T多态性与总人群PE发病风险有相关性[T vs.C:OR=1.61,95%CI(1.17,2.22),P=0.003;TT vs.CC:OR=2.65,95%CI(1.37,5.11),P=0.004;CT vs.CC:OR=1.55,95%CI(1.09,2.22),P=0.02;TT+CT vs.CC:OR=1.68,95%CI(1.15,2.45),P=0.007;TT vs.CT+CC:OR=2.19,95%CI(1.31,3.68),P=0.003]。亚组分析结果显示,VEGF基因936C/T多态性可能与亚洲人群发病风险有相关性,而与高加索人群发病风险无相关性。结论 VEGF基因936C/T多态性可能与亚洲人PE的发病风险相关。由于纳入研究数量及质量的限制,该结论需进一步进行验证。
Objective To evaluate the association between the 936C / T polymorphism of vascular endothelial growth factor (VEGF) gene and the risk of preeclampsia (PE). Methods PubMed, EMbase, The Cochrane Library (Issue 11, 2014), CBM, CNKI, VIP and Wan Fang Data were searched to find out the case-control study on the association between the 936C / T polymorphism of VEGF gene and the risk of PE , The search time limit is to build the library until November 2014. After two reviewers independently screened the literature for inclusion and exclusion, extracted data, and assessed the risk of being included in the study, Meta-analysis was performed using Rev Man 5.3 software. Results Nine case-control studies were included, for a total of 904 patients with PE and 1,113 controls. Meta-analysis showed that the 936C / T polymorphism of VEGF gene was associated with the risk of PE in the general population [T vs. C: OR = 1.61, 95% CI 1.17, 2.22, P = 0.003; OR = 2.65, 95% CI (1.37, 5.11), P = 0.004; CT vs. CC: OR = 1.55, 95% CI 95% CI (1.15, 2.45), P = 0.007; TT vs. CT + CC: OR = 2.19, 95% CI (1.31, 3.68), P = 0.003]. Subgroup analysis showed that the 936C / T polymorphism of VEGF gene may be related to the risk of Asian population, but not to the risk of Caucasian population. Conclusion The 936C / T polymorphism of VEGF gene may be associated with the risk of PE in Asians. This conclusion needs further validation due to the inclusion of the quantitative and qualitative limitations of the study.