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[目的]探讨高尿酸血症(HUA)人群血糖、血脂代谢特点。[方法]检测宜昌市444例HUA人群和498例同年龄段血尿酸(UA)正常体检者空腹血清UA、葡萄糖(FBG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c)、三酰甘油(TG)浓度,并进行比较分析。[结果]宜昌市体检人群HUA检出率为20.9%。与UA正常组比较,HUA组血清FBG、TC、TG、LDL-C均值增高,而HDL-C浓度下降(P﹤0.01),且均具有显著统计学意义(P﹤0.01),其中,TG均值上升幅度最大,达60%;HUA组血清FBG、TC、TG、HDL-C、LDL-C异常检出率较UA正常组升高,且具显著统计学意义(P﹤0.01)。HUA组各指标异常检出率由高至低分别为TG(55.6%)、LDL-C(29.8%)、TC(20.5%)、FBG(14.0%)、HDL-C(7.4%)。[结论]HUA在体检人群中具有较高的检出率,HUA与高血糖、高血脂等MS的多种因素密切相关,它们之间可能互为因果,也可能协同效应。HUA可作为MS的一个危险因素,对于HUA人群要积极进行生活方式或临床药物的干预。
[Objective] To investigate the characteristics of blood glucose and blood lipid metabolism in hyperuricemia (HUA) population. [Methods] The fasting serum UA, FBG, TC, HDL-c, Fcl-a and bcl-2 in 444 HUA and 498 normal subjects with the same age group of UA in Yichang were detected. LDL-c and triglyceride were compared and analyzed. [Results] The detection rate of HUA in Yichang City was 20.9%. The levels of serum FBG, TC, TG and LDL-C in the HUA group were significantly higher than those in the normal UA group (P <0.01), and the levels of HDL-C were significantly lower in the HUA group (P <0.01) (P <0.01). The detection rate of serum FBG, TC, TG, HDL-C and LDL-C in HUA group was significantly higher than that in UA normal group (P <0.01). In the HUA group, the abnormal detection rate of each index was TG (55.6%), LDL-C (29.8%), TC (20.5%), FBG (14.0%) and HDL-C (7.4%). [Conclusion] HUA has a high detection rate in the physical examination population. HUA is closely related to many factors such as hyperglycemia and hyperlipidemia, and may play a causal and synergistic effect with each other. HUA can be used as a risk factor for MS, for the HUA population to actively carry out lifestyle or clinical drug intervention.