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目的探讨月经紊乱不孕症育龄妇女抗苗勒管激素(AMH)表达水平与不孕症的关系。方法将229例不孕症育龄期妇女分为月经正常不孕组(120例)和月经紊乱不孕组(109例)两组,并将月经紊乱不孕组患者分为经量增多、经量减少、经期延长、经期缩短各亚组;同时设对正常照组(160例)。用化学发光法检测各组血清AMH水平。结果相同年龄段月经紊乱不孕组患者的AMH水平明显低于月经正常不孕组(P<0.05)。与正常对照组比较,月经紊乱不孕组患者的血清AMH水平,显著降低(P<0.05)。月经紊乱不孕组各亚组中,经量减少和经期缩短亚组的AMH水平显著低于其他两亚组(P均<0.05)。结论月经紊乱不孕症患者的AMH表达水平明显偏低,其中以月经经期缩短和经量减少者最严重。因此,检测月经紊乱不孕症育龄女性血清AMH表达水平,可以为评估妇女生育潜力提供参考,从而给予及时治疗。
Objective To investigate the relationship between anti-Mullerian hormone (AMH) expression and infertility in women of childbearing age with menstrual disorders. Methods 229 infertile women of childbearing age were divided into two groups: normal infertility group (120 cases) and menstrual disorder infertility group (109 cases), and the patients with menstrual disorder and infertility group were divided into three groups: Reduce, menstrual extension, menstrual shorten the subgroups; the same time set the normal group (160 cases). Chemiluminescence method was used to detect serum AMH levels in each group. Results The AMH level in patients with menstrual disorders and infertility in the same age group was significantly lower than that in normal menstruation infertility group (P <0.05). Compared with the normal control group, serum AMH levels in patients with menstrual disorders and infertility were significantly decreased (P <0.05). AMH levels in the menstrual disorders infertility subgroups were significantly lower than those in the other two subgroups (P <0.05). Conclusion AMH expression in patients with menstrual disorders and infertility was significantly lower, of which the shortening of the menstrual period and the reduction of the amount of the most serious. Therefore, the detection of serum AMH expression in women of childbearing age with infertility due to menstrual disorders can provide a reference for assessing the reproductive potential of women, so as to provide timely treatment.