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肝脏和肾脏都是药物代谢及排泄的重要器官,为预防肾功不全所致药物蓄积的副作用,应改变常规用药计划。肾功不全时,不仅药物清除率降低,而且药物的分布容积、蛋白结合率、肠道吸收率、肝脏的代谢速度、透析药物的清除和药物的相互作用等也发生变化,有时极其复杂。本文简述肾功不全病人用药的几个基本原则。
Liver and kidney are important organs of drug metabolism and excretion, to prevent side effects of drug accumulation caused by renal insufficiency, should change the conventional medication plan. Renal insufficiency not only reduces drug clearance but also changes the volume of drug distribution, the rate of protein binding, the rate of intestinal absorption, the speed of metabolism of the liver, the clearance of dialysis drugs, the interaction of drugs and the like, and is sometimes extremely complicated. This article describes several basic principles of medication for patients with renal insufficiency.