在抗菌活性物质的筛选过程中,常常会发现并分离出抗肿瘤抗生素,但由于它们的毒性大,很少用于感染症的临床治疗,然而抗肿瘤抗生素的抗菌性质可继续用作其标准化及检定的依据。利用这些药物抗菌性质的检定方法的优点是:方法简便,能实现某种程度的自动化并达到较高的精密度。但这些检定方法存在着一个明显的问题是一种药物的抗肿瘤活性能否由其抗菌活性来代表? “抗肿瘤活性”的意义是什么?在药物研究的早期阶段,意思是指药物对移植入动物体内的肿瘤细胞的活性趋势,或对培育中的特定的肿瘤细胞株生长的抑制作用。作为一种被批准的药品,“抗肿瘤活性”是指在人体内对肿瘤细胞的反应。这就依赖于有经验的 Antitumor antibiotics are often found and isolated during the screening of antimicrobial active substances but due to their high toxicity they are seldom used in the clinical treatment of infectious diseases whereas the antimicrobial properties of antitumor antibiotics can continue to be used for their standardization and Verification basis. The advantages of using the assay for antibacterial properties of these drugs are: The method is simple, achieves some degree of automation and achieves high precision. However, there is a clear problem with these assays. Is the anti-tumor activity of a drug represented by its antibacterial activity? What does “anti-tumor activity” mean? In the early stages of drug research, The tendency of tumor cells to enter animals or the inhibition of the growth of specific tumor cell lines in culture. As an approved drug, “antitumor activity” refers to the response to tumor cells in humans. It depends on experience