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目的：研究刺激延髓网状结构对脑血流量及颅内压的影响。方法：电解毁损家兔下丘脑背内侧核和中脑网状结构基础上电刺激延髓网状结构，毁损或刺激前静脉注射地塞米松５ｍｇ／ｋｇ，观察颅内压、脑血流量和脑含水量变化。结果：刺激单侧延髓网状结构后颅内压和脑血流量呈短暂可逆性增加，脑含水量无变化；强刺激双侧延髓网状结构后颅内压进行性上升，脑血流量先增加后减少，脑含水量增加。后者应用地塞米松后颅内压增高、脑血流量减少和脑水肿均减轻。结论：破坏下丘脑和中脑以及刺激延髓都将导致大脑血管紧张性降低。大剂量地塞米松可减轻脑水肿而防止颅内压进行性上升。
Objective: To study the effects of stimulation of medullary reticular formation on cerebral blood flow and intracranial pressure. Methods: Electrical stimulation of medulla oblongata network in the medial dorsal medulla and hypothalamic dorsal medulla oblongata, and dexamethasone 5 mg / kg in the anterior ventricle were emasculated or stimulated. The intracranial pressure, cerebral blood flow, Water changes. Results: The intracranial pressure and cerebral blood flow increased shortly after stimulation of unilateral medullary reticular formation, and there was no change in brain water content. After intracranial pressure was strongly stimulated by bilateral medullary reticular formation, the cerebral blood flow increased first After the decrease, increased brain water content. The latter application of dexamethasone increased intracranial pressure, decreased cerebral blood flow and cerebral edema were reduced. Conclusion: Failure of the hypothalamus and midbrain and stimulation of the medulla oblongata will result in reduced brain vascular tone. High-dose dexamethasone can reduce cerebral edema and prevent the progressive increase of intracranial pressure.