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像白细胞一样,细胞激素如TNF-α和IL-1β通过激活内皮细胞对败血症的发病机理非常重要。这些细胞激素增加组织因子的表达,组织因子在内皮细胞表面激活外凝血系统途径,减少血栓调节蛋白活性及氨基葡聚糖含量,和减少内皮细胞抗血栓形成能力。内皮细胞E-选择素(E-Selectin),一种能激活中性粒细胞粘附到内皮细胞的内皮白细胞粘稠分子表达也增加。在中性粒细胞引起内皮细胞损伤中,E-选择素介导激活的中性粒细
Like leukocytes, cytokines such as TNF-α and IL-1β are important for the pathogenesis of sepsis by activating endothelial cells. These cytokines increase the expression of tissue factor, and tissue factor activates the outer coagulation system pathway on the surface of endothelial cells, decreases the activity of thrombomodulin and the content of aminodextran, and decreases the antithrombotic capacity of endothelial cells. E-Selectin, an endothelial leukocyte adhesion molecule that activates neutrophil adhesion to endothelial cells, also increases in expression. E-selectin mediates activated neutrophils in neutrophil-induced endothelial cell damage