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为了探讨连续反应时间（CRT）测定诊断亚临床肝性脑病的意义，我们用自行研制的CRT-I型微电脑测试仪检测了60例正常人和102例不同临床类型肝病病人的CRT。结果正常人对声信号和光信号刺激CRT的P10、P50、P90、P50／（P90－P10）正常值估计分别为234．3ms、264．4ms、318．0ms和1．7560及264．4ms、323．3ms、427．6ms和1．4521。慢性重型肝炎和肝硬化病人对声和光信号刺激的CRT的P10、P50和P90均较正常对照明显延长（P＜0．01，而P50／（P90－P10）比值较正常对照明显减少（P＜0．05和0．01）；各组病例对声刺激比光刺激敏感。55％的慢性重型肝炎病人和80％肝硬化在出现临床型肝性脑病前CRT延长。初步结果显示CRT测试对亚临床型肝性脑病有一定诊断价值。
In order to investigate the significance of continuous response time (CRT) in the diagnosis of subclinical hepatic encephalopathy, we tested the CRT of 60 normal subjects and 102 patients with different clinical types of liver disease using a CRT-I microcomputer tester developed by ourselves. Results The normal values of P10, P50, P90, P50 / P90 / P10 in normal subjects were 234.3 ms, 264.4 ms, 318.0 ms and 1.7560 and 264.4 ms, respectively .3ms, 427.6ms and 1.4521. The P10, P50 and P90 of CRT patients with chronic severe hepatitis and cirrhosis were significantly longer than that of the normal controls (P <0.01, P50 / (P90-P10) ratio decreased significantly compared with the normal controls (P < 0.05 and 0.01) .All cases were more sensitive to acoustic stimulation than light stimulation.55% of patients with chronic severe hepatitis and 80% of cirrhotic patients had prolonged CRT before clinical hepatic encephalopathy.Preliminary results showed that CRT test was more effective than light stimulation Clinical hepatic encephalopathy has some diagnostic value.