论文部分内容阅读
目的研究肝组织病理损害与血清胆碱酯酶、清蛋白、胆固醇及血浆凝血酶原活动度的关系。方法对135例患者肝组织进行病理分级(G1～G4)、分期(S1～S4),采用酶速率法,测定血清胆碱酯酶、清蛋白及胆固醇;采用比浊法测定血浆凝血酶原活动度。结果在慢性肝炎轻度,胆碱酯酶活力、凝血酶原活动度、清蛋白及胆固醇下降的百分率分别为20.6％,10.3％,0.0％和0.0％,中度下降的百分率分别为39.0％,24.4％,4.9％和0.0％,差异均有非常显著性意义(P均<0.001);随着肝组织炎症程度的加重(G1～G4),胆碱酯酶活力平均值分别为:136.0,111.6,91.0和20.8 μkat·L~(-1)。凝血酶原活动度平均值分别为:1.03,0.90,0.75和0.17,清蛋白平均值分别为44,43,40和28 g·L~1,胆固醇平均值分别为4.4,3.9,4.3和1.5 mmol·L~(-1),差异均有非常显著性意义(P均<0.001);随着肝组织纤维化程度的加重(S1～S4),胆碱酯酶活力平均值分别为:120.3,97.2,86.0和22.1 μkal·L~(-1),凝血酶原活动度平均值分别为:0.92,0.84,0.72和0.23,清蛋白平均值分别为43,41,40和28g·L~(-1),胆固醇平均值分别为4.1,4.5,4.2和1.7 mmol·L~(-1),差异均有非常显著性意义(P均<0.001);它们彼此间相关系数为0.565～0.778(P均<0.001)。结论血清胆碱酯酶活力较凝血酶原活动度、清蛋白及胆固醇能更敏感地反映肝脏的合成功能,能更准确地反映肝脏的病理损害程度,它们均与肝脏的病理损害呈明显的负相关。
Objective To study the relationship between pathological lesions of liver tissue and serum cholinesterase, albumin, cholesterol and plasma prothrombin activity. Methods The pathological grading (G1 ~ G4) and staging (S1 ~ S4) of 135 patients were performed. Serum cholinesterase, albumin and cholesterol were measured by enzymatic rate method. Plasma prothrombin activity degree. Results The percentage of moderately decreased cholinesterase activity, prothrombin activity, albumin and cholesterol in chronic hepatitis were 20.6%, 10.3%, 0.0% and 0.0%, respectively. The percentages of moderate decrease were 39.0% 24.4%, 4.9% and 0.0%, respectively (all P <0.001). With the aggravation of liver inflammation (G1 ~ G4), the average values of cholinesterase activity were 136.0 and 111.6 , 91.0 and 20.8 μkat · L -1. The average activity of prothrombin was 1.03, 0.90, 0.75 and 0.17 respectively, the average values of albumin were 44, 43, 40 and 28 g · L ~ 1, respectively, and the mean values of cholesterol were 4.4, 3.9, 4.3 and 1.5 mmol · L ~ (-1), the difference was significant (P <0.001). With the increase of liver fibrosis (S1 ~ S4), the average values of cholinesterase activity were 120.3 and 97.2 , 86.0 and 22.1 μkal·L -1, respectively. The average activity of prothrombin was 0.92, 0.84, 0.72 and 0.23, respectively. The average values of albumin were 43, 41, 40 and 28 g · L -1 ), And the mean cholesterol levels were 4.1, 4.5, 4.2 and 1.7 mmol·L -1, respectively (all P <0.001). The correlation coefficients were between 0.565 and 0.778 (P < 0.001). Conclusion Serum cholinesterase activity is more sensitive than prothrombin activity, albumin and cholesterol reflect the synthesis of liver function, can more accurately reflect the degree of liver pathological lesions, which are pathological lesions were significantly negative with the liver Related.