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儿科临床中常可遇到一些长期喂养困难的小儿,没有任何医学上的原因可以解释其食欲不良.近来已发现消化道功能与消化道内分泌水平有关,本文研究了12例厌食小儿的血胃泌素与生长抑素水平。12例9月～4.5岁小儿的体重和身高明显低于同龄同性别小儿,但无任何明显的疾病存在。取晨空腹周围血测基础胃泌素与生长抑素水平,进食后1h再测其变化。血胃泌素与生长抑素均采用放免法测定。结果示厌食小儿基础生长抑素水平2倍于对照组,基础胃泌素水平与对照组无差别。进食1h后生长抑素水平从餐前的237.27±31.08降至172.32±23.48ng/L,胃泌素水平与餐前无异。本文示厌食小儿血生长抑素水平显著高于正常儿童。因生长抑素抑制胃肠分泌、运动、血流量,延迟了食物的吸收,因此血生长抑素水平升高可部分解释厌食小儿的消化道功能。其生长抑素升高的原因尚待进一步研究。
Pediatric clinical often encounter some long-term feeding difficulties in children, there is no medical reason can explain the poor appetite. Recently, it has been found that gastrointestinal function and gastrointestinal endocrine levels, the study of 12 cases of anorexia children blood gastrin And somatostatin levels. 12 cases of 9 months to 4.5 years old children’s weight and height were significantly lower than the same age same-sex children, but no obvious disease exists. Take the morning fasting peripheral blood serum levels of basal gastrin and somatostatin, measured changes after 1h. Blood gastrin and somatostatin were determined by radioimmunoassay. Results showed anorexia children basal somatostatin levels of 2 times the control group, basal gastrin levels and the control group no difference. The level of somatostatin decreased from 237.27 ± 31.08 to 172.32 ± 23.48ng / L before meals, and the level of gastrin was no different from that before meals. This article shows that anorexia children blood levels of somatostatin significantly higher than normal children. Because somatostatin inhibits gastrointestinal secretion, exercise, blood flow, delayed food absorption, so elevated blood levels of somatostatin can partially explain the anorexia in children’s gastrointestinal function. The reason for the increased somatostatin remains to be further studied.