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目的 探讨血清神经元特异性烯醇化酶 (NSE)作为诊断新生儿高未结合胆红素血症合并脑组织损害的应用价值。方法 利用静脉血测定了 35例高未结合胆红素血症新生儿和 31例正常新生儿血清NSE水平。结果 高未结合胆红素患儿血清NSE水平明显高于正常对照组 (P <0 0 1) ,与总胆红素水平相关性差。结论 新生儿血清NSE水平升高与高未结合胆红素血症造成的脑细胞损害有关 ,可作为临床监测高未结合胆红素血症新生儿胆红素脑病的一个筛选指标 ,值的推广应用。
Objective To investigate the value of serum neuron-specific enolase (NSE) as a diagnostic marker for neonatal un-combined hyperbilirubinemia with brain damage. Methods Serum levels of NSE in 35 neonates with hyperbilirubinemia and 31 normal neonates were measured by venous blood. Results Serum levels of NSE in children with high un-conjugated bilirubin were significantly higher than those in normal controls (P <0.01), showing a poor correlation with total bilirubin levels. Conclusion Neonatal serum NSE levels are associated with brain cell damage caused by high unbound bilirubin and may be used as a screening index for the clinical monitoring of bilirubin encephalopathy in neonates with high unbound bilirubin. application.