运用ＰＣＲＳＳＯＰ技术对中国北方汉族人群５６ 例胃癌患者的血液和其中２２ 例患者胃癌组织灶的ＨＬＡＤＱＢ位点进行研究，结果与对照组相比，两组间基因频率无显著差异，但１０ 种等位基因型的频率显著大于对照组，分别是０３０６Ｘ／０３０６Ｘ，０３０６Ｘ／０３０４， ０３０６Ｘ／０４０１， ０２０／０２０，０５０１／０６０５２，０５０１／０６０６Ｘ，０５０１／０５０１，０５０１／０６０３，０３０７／０４０２，０３０１／０３０１（ Ｐ＜ ０．０２５），胃癌患者血液与癌灶组织ＤＱＢ位点的分型结果完全一致，符合率达１００％ 。提示：①某些ＨＬＡＤＱＢ基因型可能在胃癌的发病和病理过程中起一定的作用。②ＨＬＡＤＱＢ等位基因水平未参与胃癌组织表面ＨＬＡＤＱＢ抗原表达异常的机制 The PCRSSOP technique was used to study the HLADQB loci of 56 patients with gastric cancer and 22 of them with gastric cancer tissue lesions in northern Chinese Han population. The results showed that there was no significant difference in gene frequency between the two groups compared with the control group. The frequencies of 10 alleles were significantly greater than those of the control group, which were 0306X/0306X, 0306X/0304, 0306X/0401, 020/020, 0501/06052, 0501/0606X, 0501/0501, 0501/0603, 0307/0402, respectively. , 0301/0301 (P< 0.025). The genotyping results of DQB locus in blood and cancer tissue of gastric cancer patients were identical, with the coincidence rate of 100%. Tip: 1 Some HLA-DQB genotypes may play a role in the pathogenesis and pathological process of gastric cancer. 2The HLA-DQB alleles are not involved in the abnormal expression of HLA-DQB antigen on gastric cancer tissues