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目的观察下呼吸道支原体感染(LRTI)患儿血清中IL-4、IL-8、IL-12及干扰素γ(IFN-γ)的变化,探讨其在发病中的意义。方法采用ELISA方法测定并比较支原体肺炎患儿和健康儿童血清中IL-4、IL-8、IL-12和IFN-γ的浓度。结果LRIT患儿IL-4、IL-8浓度急性期和恢复期明显高于健康儿童(P<0.05,P<0.01),急性期低于恢复期(P<0.01);IL-12、IFN-γ浓度急性期和恢复期明显高于健康儿童(P<0.05,P<0.01),急性期高于恢复期(P<0.01)。结论LRIT患儿存在Th1/Th2失衡,急性期Th1优势应答,恢复期Th2优势应答。
Objective To observe the changes of serum IL-4, IL-8, IL-12 and IFN-γ in children with lower respiratory tract mycoplasma infection (LRTI) and to explore its significance in the pathogenesis. Methods Serum levels of IL-4, IL-8, IL-12 and IFN-γ in children with mycoplasma pneumonia and healthy children were measured and compared by ELISA. Results The levels of IL-4 and IL-8 in children with LRIT at acute and recovery stages were significantly higher than those in healthy children (P <0.05, P <0.01), those at acute stage were lower than those at recovery (P <0.01) γ concentration in acute phase and convalescent phase was significantly higher than that in healthy children (P <0.05, P <0.01), acute phase was higher than convalescence phase (P <0.01). Conclusion There is an imbalance of Th1 / Th2 in children with LRIT, a predominant Th1 response in acute phase, and a predominant Th2 response in convalescent phase.